Participation of Plasminogen Activator/Plasmin System in Cell-cell Adhesion and Invasive Growth of Oral Squamous Cell Carcinoma Cells
Plasminogen Activator/Plasmin System, E-cadherin, α2-antiplasmin
Graduate School of Advanced Sciences of Matter Department of Molecular Biotechnology
firstname.lastname@example.org Basic Biology、 Chromosome Dynamics
is well known that the plasmin plays a main role in extracellular matrix (ECM) proteases, and regulates tumor
invasion and metastasis. In addition, it is indicated that the plasmin regulates the proteolytic processing and
affects the expression and function of cell membrane proteins. However, it isn’t being cleared a role of
plasminogen activator/plasmin system in the fragmentation, expression and function of E-cadherin which regulates cell-cell adhesion. I thought that if the plasmin suppresses the function of E-cadherin, impairs the intercellular adhesion and facilitates the cell migration of squamous cell carcinoma (SCC ) cells. Therefore, it
was suggested that the inhibition of plasmin activity not only suppresses the proteolytic activity but reduces the migration of cancer cells, and suppresses tumor invasion and metastasis.
E-cadherin on oral SCC cells was investigated. Moreover, it was examined whether the induction of α2-antiplasmin (α2-AP) which is the plasmin inhibitor affects expression of E-cadherin and the cell aggregation and invasive growth of oral SCC cells.
Oncology Reports 17: 417-423, 2007